TNIK-IN-2
TNIK-IN-2 is a Traf2- and Nck-interacting protein kinase (TNIK) inhibitor, with an IC50 of 1.3337 μM. TNIK-IN-2 can be used for the study of colorectal cancer (CRC) [1].
Product Specifications
CAS Number
[2754265-76-2]
UNSPSC
12352005
Target
Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tnik-in-2.html
Purity
99.68
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
COC1=CC(NC(C2=CC=C(C=C2OC)C3=CC4=C(NC=C4)N=C3)=O)=CC=C1
Molecular Formula
C22H19N3O3
Molecular Weight
373.40
References & Citations
[1]Li Y, et, al. Discovery of 3,4-Dihydrobenzo[ f][1,4]oxazepin-5 (2 H) -one Derivatives as a New Class of Selective TNIK Inhibitors and Evaluation of Their Anti-Colorectal Cancer Effects. J Med Chem. 2022 Jan 5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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