AR-9281

AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (s-EH) inhibitor. AR-9281 can inhibits human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively. AR9281 can be used for the research of inflammation, hypertension and type 2 diabetes[1][2].

Product Specifications

CAS Number

[913548-29-5]

Product Name Alternative

APAU

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Epoxide Hydrolase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ar-9281.html

Purity

99.69

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(NC1(C2)CC3CC2CC(C3)C1)NC4CCN(C(C)=O)CC4

Molecular Formula

C18H29N3O2

Molecular Weight

319.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Fangyu Du, et al. Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis. Eur J Med Chem. 2021 Nov 5;223:113678. |[2]Kathleen Guglielmino, et al. Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats. Am J Physiol Heart Circ Physiol. 2012 Oct 1;303 (7) :H853-62.