Fz7-21 (TFA)
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 TFA impairs the function of FZD7 in Wnt-β-catenin signalling and stem cell function in intestinal organoids[1][2].
Product Specifications
Product Name Alternative
Ac-LPSDDLEFWCHVMY-NH2 (TFA)
UNSPSC
12352209
Target
Wnt
Type
Peptides
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fz7-21-tfa.html
Purity
98.12
Solubility
DMSO : 33.33 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
Molecular Formula
C85H115N18F3O25S2
Molecular Weight
1910.07
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Citation 01
Cell Mol Life Sci. 2022 Sep 19;79 (10) :523.|Stem Cell Res Ther. 2023 Oct 26;14 (1) :305.|Cell Prolif. 2023 Oct;56 (10) :e13460.
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