Fz7-21 (TFA)

Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 TFA impairs the function of FZD7 in Wnt-β-catenin signalling and stem cell function in intestinal organoids[1][2].

Product Specifications

Product Name Alternative

Ac-LPSDDLEFWCHVMY-NH2 (TFA)

UNSPSC

12352209

Target

Wnt

Type

Peptides

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fz7-21-tfa.html

Purity

98.12

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C(N1[C@@H](CCC1)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CS)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](C(C)C)C(N[C@@H](CCSC)C(N[C@@H](CC6=CC=C(C=C6)O)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)NC(C)=O.O=C(O)C(F)(F)F

Molecular Formula

C85H115N18F3O25S2

Molecular Weight

1910.07

References & Citations

[1]Nile AH, et, al. A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 2018 Jun;14 (6) :582-590.|[2]Larasati Y, et, al. Unlocking the Wnt pathway: Therapeutic potential of selective targeting FZD7 in cancer. Drug Discov Today. 2022 Mar;27 (3) :777-792.