7-Methyl-6-thioguanosine

7-Methyl-6-thioguanosine (MESG) is a chromogenic substrate that can be converted to 7-methyl-6-thioguanine in the presence of purine nucleoside phosphorylase and inorganic phosphate. 7-Methyl-6-thioguanosine can be used to quantify inorganic phosphate. 7-Methyl-6-thioguanosine can also be used to determine the activities of purine nucleoside phosphorylase and protein phosphatases[1][2].

Product Specifications

CAS Number

[55727-10-1]

Product Name Alternative

MESG

UNSPSC

12171500

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/MESG.html

Purity

99.0

Solubility

DMSO : ≥ 250 mg/mL|H2O : ≥ 125 mg/mL

Smiles

S=C1NC(N)=NC2=C1[N+](C)=CN2[C@H]3[C@@H]([C@@H]([C@@H](CO)O3)O)[O-]

Molecular Formula

C11H15N5O4S

Molecular Weight

313.33

References & Citations

[1]Cheng Q, et al. A continuous spectrophotometric assay for protein phosphatases. Anal Biochem. 1995 Mar 20;226 (1) :68-73.|[2]Anna-Maja Aberg, et al. Effects of some modulators on purine nucleoside phosphorylase activity in myocardial tissue. Scand J Clin Lab Invest. 2010 Feb;70 (1) :8-14.