N-Bis (2-hydroxypropyl) nitrosamine

N-Bis (2-hydroxypropyl) nitrosamine is a tumor model inducing agent and a metabolite of di-n-propylnitrosamine (DPN) . N-Bis (2-hydroxypropyl) nitrosamine can be used to construct pancreatic cancer[1][2].

Product Specifications

CAS Number

[53609-64-6]

Product Name Alternative

Di (2-hydroxypropyl) nitrosamine; Diisopropanolnitrosamine

UNSPSC

12352211

Hazard Statement

H317, H319, H351

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/N-Bis_2-hydroxypropyl_nitrosamine.html

Purity

98.0

Solubility

DMSO : ≥ 125 mg/mL

Smiles

O=NN(CC(O)C)CC(O)C

Molecular Formula

C6H14N2O3

Molecular Weight

162.19

Precautions

H317, H319, H351

References & Citations

[1]Konishi Y, et al. Effect of dose on the carcinogenic activity of orally administered N-bis (2-hydroxypropyl) nitrosamine in rats. Gan. 1978 Aug;69 (4) :573-7.|[2]Zhang J, et al. Low dose of Bisphenol A enhance the susceptibility of thyroid carcinoma stimulated by DHPN and iodine excess in F344 rats. Oncotarget. 2017 Jul 22;8 (41) :69874-69887.|[3]Pour P, et al. Effect of beta-oxidized nitrosamines on syrian hamsters. III. 2,2'-Dihydroxydi-n-propylnitrosamine. J Natl Cancer Inst. 1975 Jan;54 (1) :141-6.|[4]Pour P, et al. Cancer of the pancreas induced in the Syrian golden hamster. Am J Pathol. 1974 Aug;76 (2) :349-58.