2-Methylvaleric acid

2-Methylvaleric acid is a branched short-chain fatty acid (SCFA) produced by the metabolism of branched-chain amino acids by gut microbes. 2-Methylvaleric acid can be used as a potential biomarker for metabolic diseases such as type 2 diabetes, and its content is significantly reduced in the feces of diabetic mice. 2-Methylvaleric acid may regulate host energy metabolism and inflammatory response through G protein-coupled receptors (GPCRs) or histone deacetylase (HDAC) inhibition. 2-Methylvaleric acid can be used to study gut microbe-host interactions and metabolic diseases as a fecal biomarker[1][2].

Product Specifications

CAS Number

[97-61-0]

Product Name Alternative

2-Methylpentanoic acid

UNSPSC

12352211

Hazard Statement

H227, H314

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2-methylvaleric-acid.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCC(C)C(O)=O

Molecular Formula

C6H12O2

Molecular Weight

116.16

Precautions

H227, H314

References & Citations

[1]Menghan Li, et al. A sensitive method for the quantification of short-chain fatty acids by benzyl chloroformate derivatization combined with GC-MS. Analyst. 2020 Apr 7;145 (7) :2692-2700.|[2]StoneSá, et al. Phytochemistry and antimicrobial activity of Campomanesia adamantium. Revista Brasileira de Farmacognosia. Volume 28, Issue 3, May-June 2018, Pages 303-311