D-Lin-MC3-DMA

D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

Product Specifications

CAS Number

[1224606-06-7]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Liposome

Type

Oligonucleotides

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/D-Lin-MC3-DMA.html

Purity

99.9100

Solubility

DMSO : 200 mg/mL (ultrasonic) |Ethanol : 125 mg/mL (ultrasonic)

Smiles

O=C(OC(CCCCCCCC/C=C\C/C=C\CCCCC)CCCCCCCC/C=C\C/C=C\CCCCC)CCCN(C)C

Molecular Formula

C43H79NO2

Molecular Weight

642.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Kulkarni JA, et al. Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA. Nanomedicine. 2017 May;13 (4) :1377-1387.|[2]Ferraresso F, Strilchuk AW, Juang LJ, Poole LG, Luyendyk JP, Kastrup CJ. Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells. Mol Pharm. 2022;19 (7) :2175-2182.