All-trans-4-Oxoretinoic acid
All-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs) .
Product Specifications
CAS Number
38030-57-8
Product Name Alternative
All-trans 4-Keto Retinoic Acid
UNSPSC
12352211
Hazard Statement
H361
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/all-trans-4-Oxoretinoic_acid.html
Purity
98.03
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(/C=C/C=C(/C=C/C1=C(C(CCC(C)1C)=O)C)C)=C\C(O)=O
Molecular Formula
C20H26O3
Molecular Weight
314.42
Precautions
H361
References & Citations
[1]Topletz AR, et al. Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids. Mol Pharmacol. 2015;87 (3) :430-41.|[2]Stahl W, et al. 4-oxo-retinoic acid is generated from its precursor canthaxanthin and enhances gap junctional communication in 10T1/2 cells. Adv Exp Med Biol. 1996;387:121-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Available Sizes
Frequently Asked Questions
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