All-trans-4-Oxoretinoic acid

All-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs) .

Product Specifications

CAS Number

[38030-57-8]

Product Name Alternative

All-trans 4-Keto Retinoic Acid

UNSPSC

12352211

Hazard Statement

H361

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/all-trans-4-Oxoretinoic_acid.html

Purity

98.03

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(/C=C/C=C(/C=C/C1=C(C(CCC(C)1C)=O)C)C)=C\C(O)=O

Molecular Formula

C20H26O3

Molecular Weight

314.42

Precautions

H361

References & Citations

[1]Topletz AR, et al. Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids. Mol Pharmacol. 2015;87 (3) :430-41.|[2]Stahl W, et al. 4-oxo-retinoic acid is generated from its precursor canthaxanthin and enhances gap junctional communication in 10T1/2 cells. Adv Exp Med Biol. 1996;387:121-8.