SecinH3
SecinH3 is an antagonist of cytohesins with IC50s of 5.4 μM, 2.4 μM, 5.4 μM, 5.6 μM, 5.6 μM and 65 μM for hCyh1, hCyh2, mCyh3, hCyh3, drosophila steppke and yGea2-S7, respectively.
Product Specifications
CAS Number
[853625-60-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Endocrinology; Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/SecinH3.html
Purity
99.70
Solubility
DMSO : 130 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(N2N=C(OC)N=C2C3=CC=C(OCO4)C4=C3)C=C1)CSC5=CC=CC=C5
Molecular Formula
C24H20N4O4S
Molecular Weight
460.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Hafner M, et al. Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance. Nature. 2006 Dec 14;444 (7121) :941-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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