pan-KRAS-IN-5
Product Specifications
UNSPSC Description
pan-KRAS-IN-5 (compound 15a) is a pan-KRAS translation inhibitor by targeting 5′-UTR RNA G-quadruplexes (rG4s). pan-KRAS-IN-5 induces cell cycle arrest and promptes apoptosis in KRAS-driven cancer cells[1].
Target Antigen
Apoptosis; Ras
Type
Reference compound
Related Pathways
Apoptosis;GPCR/G Protein;MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-kras-in-5.html
Solubility
10 mM in DMSO
Smiles
C[N+]1=C(/C=C/C2=CC3=CC=C(N(CC)CC)C=C3OC2=O)C=CC4=C1C=C(NCCN5CCCC5)C(F)=C4.[I-]
Molecular Weight
642.55
References & Citations
[1]Mao-Lin Li, et al. Discovery of Novel Coumarin-quinolinium Derivatives as Pan-KRAS Translation Inhibitors by Targeting 5'-UTR RNA G-Quadruplexes. J Med Chem. 2024 Feb 8;67(3):1961-1981.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163299/pan-KRAS-IN-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163299/pan-KRAS-IN-5-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
3027172-23-9
Available Sizes
Curated Selection
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