Pan-KRAS-IN-5

Pan-KRAS-IN-5 is a pan-KRAS translation inhibitor by targeting 5′-UTR RNA G-quadruplexes (rG4s) . pan-KRAS-IN-5 strongly binds to and stabilizes KRAS rG4s, inhibits KRAS translation, and blocks the MAPK and PI3K-AKT pathways. pan-KRAS-IN-5 induces cell cycle arrest, prompts apoptosis in KRAS-driven cancer cells. pan-KRAS-IN-5 inhibits tumor growth and KRAS expression in KRAS-mutant xenograft. KRAS-IN-5 can be used for KRAS-driven cancer research[1].

Product Specifications

CAS Number

[3027172-23-9]

UNSPSC

12352005

Target

Akt; Apoptosis; p38 MAPK; PI3K; Ras

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pan-kras-in-5.html

Purity

96.70

Solubility

10 mM in DMSO

Smiles

C[N+]1=C(/C=C/C2=CC3=CC=C(N(CC)CC)C=C3OC2=O)C=CC4=C1C=C(NCCN5CCCC5)C(F)=C4.[I-]

Molecular Formula

C31H36FIN4O2

Molecular Weight

642.55

References & Citations

[1]Mao-Lin Li, et al. Discovery of Novel Coumarin-quinolinium Derivatives as Pan-KRAS Translation Inhibitors by Targeting 5'-UTR RNA G-Quadruplexes. J Med Chem. 2024 Feb 8;67 (3) :1961-1981.