Indole-3-pyruvic acid

Indole-3-pyruvic acid, a keto analogue of tryptophan, is an orally active AHR agonist. Indole-3-pyruvic acid has antioxidant properties, and can be used in the research of inflammation, anxiety[1][2][3].

Product Specifications

CAS Number

[392-12-1]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Aryl Hydrocarbon Receptor; Endogenous Metabolite

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/indole-3-pyruvic-acid.html

Purity

99.55

Solubility

DMSO : 166.67 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL|H2O : 20 mg/mL (ultrasonic; adjust pH to 12 with NaOH)

Smiles

O=C(O)C(CC1=CNC2=CC=CC=C12)=O

Molecular Formula

C11H9NO3

Molecular Weight

203.20

Precautions

H315, H319, H335

References & Citations

[1]Reiji Aoki, et al. Indole-3-Pyruvic Acid, an Aryl Hydrocarbon Receptor Activator, Suppresses Experimental Colitis in Mice. J Immunol. 2018 Dec 15;201 (12) :3683-3693. |[2]Reiji Aoki, et al. Protective effect of indole-3-pyruvate against ultraviolet b-induced damage to cultured HaCaT keratinocytes and the skin of hairless mice. PLoS One. 2014 May 8;9 (5) :e96804. |[3]I P Lapin, et al. Anxiolytic effect of indole-3-pyruvic acid (IPA) in mice. Pharmacol Res. 1993 Sep;28 (2) :129-34.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Microbial Metabolite

Available Sizes

Curated Selection

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