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Alendronic acid

Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget’s disease[1].

Product Specifications

CAS Number

[66376-36-1]

UNSPSC

12352211

Hazard Statement

H314, H315

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/alendronic-acid.html

Concentration

10mM

Purity

99.9

Solubility

H2O : 3.7 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(P(O)(O)=O)(CCCN)P(O)(O)=O

Molecular Formula

C4H13NO7P2

Molecular Weight

249.10

Precautions

H314, H315

References & Citations

[1]Teixeira S, et al. Alendronic Acid as Ionic Liquid: New Perspective on Osteosarcoma. Pharmaceutics. 2020 Mar 24;12 (3) . pii: E293.|[2]Duckworth AD, et al. Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo-Controlled Trial. J Bone Miner Res. 2019 Jun;34 (6) :1025-1032.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Cell Rep. 2022 Oct 25;41 (4) :111508.|Am J Physiol Endocrinol Metab. 2024 May 8.|Bone. 2024 Nov 29:192:117348.|Int J Mol Sci. 2024 Jul 16;25 (14) :7798.|J Biol Chem. 2019 Jul 19;294 (29) :11240-11247.|J Med Chem. 2024 Sep 12;67 (17) :15738-15755.|Pathol Res Pract. 2025 Sep:273:156138.|Biochem Pharmacol. 2025 Aug 13;242 (Pt 1) :117234.|Int J Mol Med. 2025 Dec;56 (6) :206.|J Pharm Anal. 2025 Jul 31.

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