Ruxolitinib (S enantiomer)
Selected Variant
HY-50856A-01
Size: 5 mg
Ruxolitinib (S enantiomer) (S-Ruxolitinib) is the S-enantiomer of Ruxolitinib. Ruxolitinib (S enantiomer) is an orally active, potent JAK inhibitor[1][2].
Product Specifications
CAS Number
941685-37-6
Product Name Alternative
S-Ruxolitinib; S-INCB18424
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ruxolitinib-s-enantiomer.html
Concentration
10mM
Purity
99.94
Solubility
1M HCl : 50 mg/mL (ultrasonic; adjust pH to 1 with HCl) |DMSO : ≥ 100 mg/mL
Smiles
N#CC[C@@H](C1CCCC1)N2N=CC(C3=NC=NC4=C3C=CN4)=C2
Molecular Formula
C17H18N6
Molecular Weight
306.37
References & Citations
[1]Hye Kyung Lee, et al. JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells. Commun Biol. 2021 Jun 2;4 (1) :654.|[2]Lorena Arranz, et al. Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms. Nature. 2014 Aug 7;512 (7512) :78-81.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
JAK
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