Vidofludimus

Vidofludimus is an orally active inhibitor for dihydroorotate dehydrogenase (DHODH) and also is a novel modulator for farnesoid X receptor (FXR) . Vidofludimus, as an immunomodulatory agent, can be used for the research of autoimmune disorders such as inflammatory bowel disease (IBD) . Vidofludimus also can be used for the research of fatty liver by targeting FXR[1][2][3].

Product Specifications

CAS Number

[717824-30-1]

Product Name Alternative

4sc-101; SC12267

UNSPSC

12352005

Hazard Statement

H302

Target

Dihydroorotate Dehydrogenase; FXR; Interleukin Related

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Vidofludimus.html

Purity

99.14

Solubility

DMSO : ≥ 46 mg/mL

Smiles

O=C(C1=C(C(NC2=CC=C(C3=CC=CC(OC)=C3)C=C2F)=O)CCC1)O

Molecular Formula

C20H18FNO4

Molecular Weight

355.36

Precautions

H302

References & Citations

[1]Yanlin Zhu, et al. Repositioning an Immunomodulatory Drug Vidofludimus as a Farnesoid X Receptor Modulator With Therapeutic Effects on NAFLD. Front Pharmacol. 2020 May 14;11:590. |[2]Andreas Muehler, et al. Vidofludimus calcium, a next generation DHODH inhibitor for the Treatment of relapsing-remitting multiple sclerosis. Mult Scler Relat Disord. 2020 Aug;43:102129.|[3]Leo R Fitzpatrick, et al. Vidofludimus inhibits colonic interleukin-17 and improves hapten-induced colitis in rats by a unique dual mode of action. J Pharmacol Exp Ther. 2012 Sep;342 (3) :850-60.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

IL-17

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

474309 100 µL

Salmonella Enteritidis

Ask

View Details

B1651 96 Tests

Adipocyte Fatty Acid-binding Protein 4 (a-FABP4) Rabbit ELISA Kit

Ask

View Details