What is the catalog number for B-AP15?

The catalog number for B-AP15 is HY-13989.

What sizes are available for B-AP15?

B-AP15 is available in the following size(s): 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 500 mg.

How many pack sizes does B-AP15 come in?

B-AP15 is available in 7 different pack sizes.

B-AP15 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures B-AP15?

B-AP15 is manufactured by QuantiMol.

What is the estimated delivery time for B-AP15?

Estimated delivery time for B-AP15 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for B-AP15?

The safety data sheet for B-AP15 is available here: http://file.medchemexpress.com/batch_PDF/HY-13989/b-AP15-SDS-MedChemExpress.pdf.

B-AP15

B-AP15 is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14.

Product Specifications

CAS Number

1009817-63-3

Product Name Alternative

NSC 687852

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Deubiquitinase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/b-AP15.html

Purity

98.93

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

O=C1/C(CN(C(C=C)=O)C/C1=C\C2=CC=C([N+]([O-])=O)C=C2)=C/C3=CC=C([N+]([O-])=O)C=C3

Molecular Formula

C22H17N3O6

Molecular Weight

419.39

Precautions

H302, H315, H319, H335

References & Citations

[1]D'Arcy P, et al. Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat Med. 2011 Nov 6;17 (12) :1636-40.|[2]Wang X, et al. The 19S Deubiquitinase Inhibitor b-AP15 is Enriched in Cells and Elicits Rapid Commitment to Cell Death. Mol Pharmacol. 2014 Jun;85 (6) :932-45.|[3]Tian Z, et al. A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance. Blood. 2014 Jan 30;123 (5) :706-16.