b-AP15
Product Specifications
UNSPSC Description
b-AP15 is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14.
Target Antigen
Apoptosis; Deubiquitinase
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/b-AP15.html
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C1/C(CN(C(C=C)=O)C/C1=C\C2=CC=C([N+]([O-])=O)C=C2)=C/C3=CC=C([N+]([O-])=O)C=C3
Molecular Weight
419.39
References & Citations
[1]D'Arcy P, et al. Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat Med. 2011 Nov 6;17(12):1636-40.|[2]Wang X, et al. The 19S Deubiquitinase Inhibitor b-AP15 is Enriched in Cells and Elicits Rapid Commitment to Cell Death. Mol Pharmacol. 2014 Jun;85(6):932-45.|[3]Tian Z, et al. A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance. Blood. 2014 Jan 30;123(5):706-16.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13989/b-AP15-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13989/b-AP15-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1009817-63-3
Available Sizes
Curated Selection
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