B-AP15
B-AP15 is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14.
Product Specifications
CAS Number
1009817-63-3
Product Name Alternative
NSC 687852
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Deubiquitinase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/b-AP15.html
Purity
98.93
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C1/C(CN(C(C=C)=O)C/C1=C\C2=CC=C([N+]([O-])=O)C=C2)=C/C3=CC=C([N+]([O-])=O)C=C3
Molecular Formula
C22H17N3O6
Molecular Weight
419.39
Precautions
H302, H315, H319, H335
References & Citations
[1]D'Arcy P, et al. Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat Med. 2011 Nov 6;17 (12) :1636-40.|[2]Wang X, et al. The 19S Deubiquitinase Inhibitor b-AP15 is Enriched in Cells and Elicits Rapid Commitment to Cell Death. Mol Pharmacol. 2014 Jun;85 (6) :932-45.|[3]Tian Z, et al. A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance. Blood. 2014 Jan 30;123 (5) :706-16.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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