B-AP15

B-AP15 is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14.

Product Specifications

CAS Number

[1009817-63-3]

Product Name Alternative

NSC 687852

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Deubiquitinase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/b-AP15.html

Purity

98.93

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

O=C1/C(CN(C(C=C)=O)C/C1=C\C2=CC=C([N+]([O-])=O)C=C2)=C/C3=CC=C([N+]([O-])=O)C=C3

Molecular Formula

C22H17N3O6

Molecular Weight

419.39

Precautions

H302, H315, H319, H335

References & Citations

[1]D'Arcy P, et al. Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat Med. 2011 Nov 6;17 (12) :1636-40.|[2]Wang X, et al. The 19S Deubiquitinase Inhibitor b-AP15 is Enriched in Cells and Elicits Rapid Commitment to Cell Death. Mol Pharmacol. 2014 Jun;85 (6) :932-45.|[3]Tian Z, et al. A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance. Blood. 2014 Jan 30;123 (5) :706-16.