HAEGT

HAEGT is the first N-terminal 1-5 residues of glucagon like peptide-1 (GLP-1) peptide, and the sequence is His-Ala-Glu-Gly-Thr. HAEGT acts as a competitive substrate for probing prime substrate binding sites of human dipeptidyl peptidase-IV (DPP-IV) 1, in which the N-terminal His-Ala is catalyzed cleavage by DPP-IV. HAEGT can be used in the research of diabetes, obesity[1].

Product Specifications

CAS Number

[852155-81-8]

UNSPSC

12352209

Target

Dipeptidyl Peptidase; GLP Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/HAEGT.html

Purity

98.86

Solubility

H2O

Smiles

O=C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H]([C@H](O)C)C(O)=O)=O)=O)=O)[C@H](CC1=CNC=N1)N

Molecular Formula

C20H31N7O9

Molecular Weight

513.50

References & Citations

[1]Lisa M Kopcho, et al. Probing prime substrate binding sites of human dipeptidyl peptidase-IV using competitive substrate approach. Arch Biochem Biophys. 2005 Apr 15;436 (2) :367-76.