Cipralisant (enantiomer)

Cipralisant (GT-2331) enantiomer is the enantiomer of Cipralisant (HY-106993), Cipralisant is an orally active, potent, selective, and high affinity histamine H3 receptor antagonist (rat Ki=0.47 nM) [1][2][3][4][5]. Cipralisant (enantiomer) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[223420-11-9]

Product Name Alternative

GT-2331 (enantiomer)

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cipralisant-enantiomer.html

Purity

96.38

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)(C)CCC#C[C@@H]1[C@@H](C2=CN=CN2)C1

Molecular Formula

C14H20N2

Molecular Weight

216.32

References & Citations

[1]Liu H, et al. An efficient multigram synthesis of the potent histamine H3 antagonist GT-2331 and the reassessment of the absolute configuration. J Org Chem. 2004 Jan 9;69 (1) :192-4.|[2]Raddatz R, et al. Histamine H3 antagonists for treatment of cognitive deficits in CNS diseases. Curr Top Med Chem. 2010;10 (2) :153-69.|[3]Fox GB, et al. Effects of histamine H (3) receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup. Behav Brain Res. 2002 Apr 1;131 (1-2) :151-61.|[4]Ito S, et al. Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor. Eur J Pharmacol. 2006 Jan 4;529 (1-3) :40-6.|[5]Tedford CE, et al. High antagonist potency of GT-2227 and GT-2331, new histamine H3 receptor antagonists, in two functional models. Eur J Pharmacol. 1998 Jun 26;351 (3) :307-11.