MBX-2982

MBX-2982 is a selective, orally-available G protein-coupled receptor 119 (GPR119) agonist.

Product Specifications

CAS Number

[1037792-44-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GPR119

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/mbx-2982.html

Purity

99.68

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CCC1=CN=C(N2CCC(C3=NC(COC4=CC=C(N5N=NN=C5)C=C4)=CS3)CC2)N=C1

Molecular Formula

C22H24N8OS

Molecular Weight

448.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Hothersall JD, et al. Sustained wash-resistant receptor activation responses of GPR119 agonists. Eur J Pharmacol. 2015 Sep 5;762:430-42.|[2]Lan H, et al. Agonists at GPR119 mediate secretion of GLP-1 from mouse enteroendocrine cells through glucose-independent pathways. Br J Pharmacol. 2012 Apr;165 (8) :2799-807.|[3]Yang JW, et al. GPR119: a promising target for nonalcoholic fatty liver disease. FASEB J. 2016 Jan;30 (1) :324-35.