MBX-2982
MBX-2982 is a selective, orally-available G protein-coupled receptor 119 (GPR119) agonist.
Product Specifications
CAS Number
1037792-44-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GPR119
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/mbx-2982.html
Purity
99.68
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CCC1=CN=C(N2CCC(C3=NC(COC4=CC=C(N5N=NN=C5)C=C4)=CS3)CC2)N=C1
Molecular Formula
C22H24N8OS
Molecular Weight
448.54
Precautions
H302, H315, H319, H335
References & Citations
[1]Hothersall JD, et al. Sustained wash-resistant receptor activation responses of GPR119 agonists. Eur J Pharmacol. 2015 Sep 5;762:430-42.|[2]Lan H, et al. Agonists at GPR119 mediate secretion of GLP-1 from mouse enteroendocrine cells through glucose-independent pathways. Br J Pharmacol. 2012 Apr;165 (8) :2799-807.|[3]Yang JW, et al. GPR119: a promising target for nonalcoholic fatty liver disease. FASEB J. 2016 Jan;30 (1) :324-35.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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