DS-1-38
DS-1-38 is an EYA1 antagonist that blocks Sonic Hedgehog (SHH) signaling. EYA1 is a haloacid dehalogenase phosphatase and transcription factor that regulates tumorigenesis and proliferation in SHH medulloblastoma (SHH-MB) [1].
Product Specifications
UNSPSC
12352005
Target
Hedgehog
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ds-1-38.html
Purity
99.60
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CCC1=C(C2=C(C=CC(C3=CN(N=C3)C)=C2)O1)C(C4=CC=C(C=C4)O)=O
Molecular Formula
C21H18N2O3
Molecular Weight
346.38
References & Citations
[1]Hwang GH, et al. A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma. Cancer Res. 2024 Mar 15;84 (6) :872-886.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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