Iota-conotoxin RXIA

Product Specifications

CAS Number

[1042682-52-9]

UNSPSC Description

lota-conotoxin RXIA is an agonist of voltage-gated sodium channels (Nav1.2, 1.6, 1.7). Iota-conotoxin RXIA can induce repetitive action potential and seizure in motor axons of frogs after intracranial injection in mice [1].

Target Antigen

Sodium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

O=C(CN)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CSSCC(NC4=O)C(N[C@H](C(N5[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N6[C@H](C(NC7)=O)CCC6)=O)CC(C)C)=O)[C@H](CC)C)=O)CC8=CNC9=CC=CC=C89)=O)CC(N)=O)=O)[C@@H](C)O)=O)CO)=O)C[C@H](C5)O)=O)C)=O)=O)CC(O)=O)=O)C)=O)CC%10=CNC=N%10)=O)CC%11=CC=C(O)C=C%11)=O)CCC(O)=O)=O)CSSC[C@H](NC%12=O)C(N[C@H](C(N[C@H](C(NCC(N[C@H]4[C@H](CC)C)=O)=O)CO)=O)CC(C)C)=O)=O)C[C@H](C2)O)=O)CCCCN)=O)CCC(O)=O)=O)CC(O)=O)=O)C)=O)CCCCN)=O)CSSC[C@H](NC3=O)C(NC(C(N[C@H]%12CSSC[C@H](NC7=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)[C@H](CC)C)=O)CCCCN)=O)CC%13=CC=CC=C%13)=O)CC%14=CC=CC=C%14)=O)CO)=O)CO)=O)[C@@H](C)O)=O)CO)=O)=O)CC(N)=O)=O)=O)CC%15=CC=CC=C%15)=O)CO)=O)C[C@H](C1)O

Molecular Weight

4975.57

References & Citations

[1]Fiedler B, et al. Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7. Biochem Pharmacol. 2008 Jun 15;75(12):2334-44.