Thalidomide-O-amido-C3-COOH

Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

Product Specifications

CAS Number

[2308035-51-8]

Product Name Alternative

Cereblon Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 15

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/E3_ligase_Ligand-Linker_Conjugates_15.html

Purity

98.43

Solubility

DMSO : ≥ 55.5 mg/mL

Smiles

O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(NCCCC(O)=O)=O

Molecular Formula

C19H19N3O8

Molecular Weight

417.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53. [Content Brief]