DG051
DG051 is a potent leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis in the enzyme assay with an IC50=47 nM.
Product Specifications
CAS Number
929915-58-2
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Aminopeptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/DG051.html
Purity
99.86
Solubility
DMSO : ≥ 325 mg/mL
Smiles
Cl[H].O=C(O)CCCN1CCC[C@H]1COC(C=C2)=CC=C2OC3=CC=C(Cl)C=C3
Molecular Formula
C21H25Cl2NO4
Molecular Weight
426.33
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Sandanayaka V, et al. Discovery of 4-[ (2S) -2-{[4- (4-chlorophenoxy) phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J Med Chem. 2010 Jan 28;53 (2) :573-85.|[2]Enache LA, et al. Synthesis and structural assignment of two major metabolites of the LTA4H inhibitor DG-051. Bioorg Med Chem Lett. 2009 Nov 15;19 (22) :6275-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
LTA4H
Available Sizes
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