DG051

DG051 is a potent leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis in the enzyme assay with an IC50=47 nM.

Product Specifications

CAS Number

[929915-58-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Aminopeptidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/DG051.html

Purity

99.86

Solubility

DMSO : ≥ 325 mg/mL

Smiles

Cl[H].O=C(O)CCCN1CCC[C@H]1COC(C=C2)=CC=C2OC3=CC=C(Cl)C=C3

Molecular Formula

C21H25Cl2NO4

Molecular Weight

426.33

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Sandanayaka V, et al. Discovery of 4-[ (2S) -2-{[4- (4-chlorophenoxy) phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J Med Chem. 2010 Jan 28;53 (2) :573-85.|[2]Enache LA, et al. Synthesis and structural assignment of two major metabolites of the LTA4H inhibitor DG-051. Bioorg Med Chem Lett. 2009 Nov 15;19 (22) :6275-9.