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Genipin (Standard)

Genipin (Standard) is the analytical standard of Genipin. This product is intended for research and analytical applications. Genipin ((+) -Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research[1][2].

Product Specifications

CAS Number

6902-77-8

Product Name Alternative

(+) -Genipin (Standard)

UNSPSC

12352005

Hazard Statement

H301

Target

Autophagy; Reference Standards

Type

Reference Standards

Related Pathways

Autophagy; Others

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/genipin-standard.html

Purity

97.51

Smiles

O=C(C1=CO[C@@H](O)[C@@]2([H])[C@]1([H])CC=C2CO)OC

Molecular Formula

C11H14O5

Molecular Weight

226.23

Precautions

H301

References & Citations

[1]Ma C, et al. Genipin stimulates glucose transport in C2C12 myotubes via IRS-1 and calcium- dependent mechanism. J Endocrinol. 2012 Dec 20.|[2]Kim BC, et al. Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway. Biochem Pharmacol. 2005 Nov 1;70 (9) :1398-407.|[3]Ye D, et al. Genipin normalizes depression-like behavior induced by prenatal stress through inhibiting DNMT1. Epigenetics. 2018 Mar 9:1-22.|[4]Kim BC, et al. Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway. Biochem Pharmacol. 2005 Nov 1;70 (9) :1398-407.

Shipping Conditions

Blue Ice

Storage Conditions

4°C, sealed storage, away from light and moisture

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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