CAY 10465

CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM) .

Product Specifications

CAS Number

[688348-33-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Aryl Hydrocarbon Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/CAY_10465.html

Purity

98.30

Solubility

DMSO : ≥ 100 mg/mL

Smiles

FC(C1=CC=C(/C=C/C2=CC(Cl)=CC(Cl)=C2)C=C1)(F)F

Molecular Formula

C15H9Cl2F3

Molecular Weight

317.13

Precautions

H302, H315, H319

References & Citations

[1]de Medina P, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48 (1) :287-91.|[2]Naem E, et al. Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia. Life Sci. 2012 Jul 26;91 (1-2) :64-9.