Gap 26
Product Specifications
UNSPSC Description
Gap 26 is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif[1].
Target Antigen
Gap Junction Protein
Type
Peptides
Related Pathways
Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Gap_26.html
Purity
99.95
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
[V]C([2H])([K])/[Y]=S(P(/S=[V]/[R])I)\F
Molecular Weight
1550.78
References & Citations
[1]Katleen Braet, et al. Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium. 2003 Jan;33(1):37-48.|[2]Chaytor AT, et al. Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J Physiol. 1997 Aug 15;503 ( Pt 1):99-110.ACS Chem Biol. 2020 Jun 19;15(6):1392-1400.|Biomed Pharmacother. 2022 Apr 22;150:112973.|Cell Metab. 2021 Feb 2;33(2):283-299.e9.|Lab Invest. 2021 Sep 14.|Medicina (Kaunas). 2024 May 8;60(5):780.|Toxicology. 2022 Aug 4;153283.|Cureus. 2024 Apr 26.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P1082/Gap-26-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P1082/Gap-26-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
197250-15-0
Available Sizes
Curated Selection
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