ML-7

ML-7 is a myosin light chain kinase inhibitor with the activity to inhibit superoxide anion (O (2) (-) ) release in human neutrophils. ML-7 can affect the activity of neutrophils independently of myosin light chain kinase. ML-7 inhibits the extracellular O (2) (-) release of stimulated cells, but has no effect on the intracellular O (2) (-) production. ML-7 also strongly inhibits the binding of the intracellular compartment of oxide production to the cell membrane, indicating that it plays a key role in stimulated neutrophils. At the same time, ML-7 protects cardiac function from ischemia/reperfusion injury[1].