NLRP3-IN-13

NLRP3-IN-13 (Compound C77 in reference patent) is a selective and potent NLRP3 inhibitor (IC50: 2.1 μM) . NLRP3-IN-13 inhibits NLRP3 andNLRC4 inflammasomes, and inhibits NLRP3-mediated IL-1β production. NLRP3-IN-13 also inhibits NLRP3 ATPase activity. NLRP3-IN-13 can be used in the research of neuroinflammatory disorders[1].

Product Specifications

CAS Number

[1704638-35-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nlrp3-in-13.html

Purity

98.03

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1OC2=C(N1CC(NCC3=CN=CC(C4=CSC=C4)=C3)=O)C=CC=C2

Molecular Formula

C19H15N3O3S

Molecular Weight

365.41

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Devita Robert, et al. Benzoxazolones as inhibitors of inflammasomes and their preparation. Patent. WO2022187804.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NLRP3

Available Sizes

Curated Selection

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