Pomalidomide-C6-COOH

Pomalidomide-C6-COOH is the pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-OH can be connected to the ligand for protein by a linker to form PROTAC[1].

Product Specifications

CAS Number

[2225940-50-9]

UNSPSC

12352005

Hazard Statement

H361

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pomalidomide-c6-cooh.html

Purity

98.02

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(O)CCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O

Molecular Formula

C20H23N3O6

Molecular Weight

401.41

Precautions

H361

References & Citations

[1]Xiaojuan Qu, et al. Effective degradation of EGFRL858R+T790M mutant proteins by CRBN-based PROTACs through both proteosome and autophagy/lysosome degradation systems. Eur J Med Chem. 2021.