PPARδ agonist 10

PPARδ agonist 10 (compound 7) is an orally active, selective, and partial agonist of PPARδ, with EC50 values of 0.053 μM and 0.30 µM for hPPARδ (LBD) -GAL4 and mPPARδ, respectively. PPARδ agonist 10 is a partial PPARδ agonist in transactivation assay but a full agonist on free fatty acids (FFA) oxidation in muscle cells both in vitro and in vivo. PPARδ agonist 10 can be used for dyslipidemia research[1].

Product Specifications

CAS Number

[685139-10-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pparδ-agonist-10.html

Solubility

10 mM in Ethanol

Smiles

O=C(COC1=CC=C(C=C1Cl)SC/C=C(C2=CC=C(C=C2)Br)/C3=CC=C(C=C3)Br)O

Molecular Formula

C23H17Br2ClO3S

Molecular Weight

568.71

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Sauerberg P, et al. Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo. J Med Chem. 2007 Apr 5;50 (7) :1495-503.