ARC 239 (dihydrochloride)
ARC 239 dihydrochloride is a selective α2B/2C adrenoceptor antagonist (pKd values are 5.95, 7.41 and 7.56 at α2A, α2B, and α2C receptors respectively) . ARC 239 dihydrochloride binds to CHO cell membranes expressing human recombinant a2A-, a2B- or a2C-adrenoceptor subtypes with pKis of 5.6, 8.4, and 7.08, respectively[1].
Product Specifications
CAS Number
55974-42-0
UNSPSC
12352005
Hazard Statement
H302, H400, H410
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/arc-239-dihydrochloride.html
Purity
99.20
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(C(C)(C)C(N1CCN3CCN(CC3)C4=C(OC)C=CC=C4)=O)C=CC=C2.Cl.Cl
Molecular Formula
C24H31Cl2N3O3
Molecular Weight
480.43
Precautions
H302, H400, H410
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MLAG-3; α adrenergic receptor
Available Sizes
Frequently Asked Questions
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