ARC 239 (dihydrochloride)

ARC 239 dihydrochloride is a selective α2B/2C adrenoceptor antagonist (pKd values are 5.95, 7.41 and 7.56 at α2A, α2B, and α2C receptors respectively) . ARC 239 dihydrochloride binds to CHO cell membranes expressing human recombinant a2A-, a2B- or a2C-adrenoceptor subtypes with pKis of 5.6, 8.4, and 7.08, respectively[1].

Product Specifications

CAS Number

[55974-42-0]

UNSPSC

12352005

Hazard Statement

H302, H400, H410

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/arc-239-dihydrochloride.html

Purity

99.20

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=C(C(C)(C)C(N1CCN3CCN(CC3)C4=C(OC)C=CC=C4)=O)C=CC=C2.Cl.Cl

Molecular Formula

C24H31Cl2N3O3

Molecular Weight

480.43

Precautions

H302, H400, H410

References & Citations

[1]M R Corboz, et al. Pharmacological characterization of alpha 2-adrenoceptor-mediated responses in pig nasal mucosa. Auton Autacoid Pharmacol. 2003 Aug;23 (4) :208-19.