SB-616234-A

SB-616234-A is a selective and orally bioavailable 5-HT1B receptor antagonist, with anxiolytic and antidepressant activity.

Product Specifications

CAS Number

[908601-49-0]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/SB-616234A.html

Purity

99.40

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1CCC2=C1C=C(N3C[C@@H](C)N[C@@H](C)C3)C(OC)=C2)C4=CC=C(C5=CC=C(C6=NOC(C)=N6)C=C5C)C=C4.[H]Cl

Molecular Formula

C32H36ClN5O3

Molecular Weight

574.11

References & Citations

[1]Lee A.Dawson, et al. Characterisation of the selective 5-HT1B receptor antagonist SB-616234-A (1-[6- (cis-3,5-dimethylpiperazin-1-yl) -2,3-dihydro-5-methoxyindol-1-yl]-1-[2′-methyl-4′- (5-methyl-1,2,4-oxadiazol-3-yl) biphenyl-4-yl]methanone hydrochloride) : In vivo neurochemical and behavioural evidence of anxiolytic/antidepressant activity. Neuropharmacology Volume 50, Issue 8, June 2006, Pages 975-983|[2]Scott C, et al. SB-616234-A (1-[6- (cis-3,5-dimethylpiperazin-1-yl) -2,3-dihydro-5-methoxyindol-1-yl]-1-[2'methyl-4'- (5-methyl-1,2,3-oxadiazol-3-yl) biphenyl-4-yl]methanone hydrochloride) : a novel, potent and selective 5-HT1B receptor antagonist. Neuropharmacology. 2006 Jun;50 (8) :984-90. Epub 2006 Mar 20.