Lofexidine-d4
Lofexidine-d4 is deuterium labeled Lofexidine (hydrochloride) . Lofexidine (hydrochloride) is a selective α2-receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal[1][2][3].
Product Specifications
CAS Number
78302-26-8
UNSPSC
12352005
Target
Adrenergic Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease; Endocrinology
Smiles
CC(C1=NC([2H])([2H])C([2H])([2H])N1)OC2=C(C=CC=C2Cl)Cl
Molecular Formula
C11H8D4Cl2N2O
Molecular Weight
263.16
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Vartak AP, et al. The preclinical discovery of lofexidine for the treatment of opiate addiction. Expert Opin Drug Discov. 2014 Nov;9 (11) :1371-7.|[3]Gish EC, et al. Lofexidine, an {alpha}2-receptor agonist for opioid detoxification. Ann Pharmacother. 2010 Feb;44 (2) :343-51.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
EKC1903 1 Kit, containing one 96 Well Plate and all necessary reagents
RPS6KC1 Colorimetric Cell-Based ELISA
Sign In for Pricing
View Details 
IRBAMLCRELD1AP223120UL 120 µL
Rabbit Anti CRELD1 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot,Immunofluorescence) 120ul
Sign In for Pricing
View Details