Suc-Gly-Pro-AMC

Suc-Gly-Pro-AMC is a fluorescent substrate. Suc-Gly-Pro-AMC is a fibroblast activation protein (FAP) specific substrate. Suc-Gly-Pro-AMC reacts with recombinant porcine prolyl oligopeptidase. Suc-Gly-Pro-AMC can be used to study the activity of FAP, prolyl endopeptidase (PREP) . Suc-Gly-Pro-AMC is used in glioma research[1][2][3].

Product Specifications

CAS Number

[80049-85-0]

UNSPSC

12352005

Target

FAP; Prolyl Endopeptidase (PREP)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/suc-gly-pro-amc.html

Purity

99.16

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

CC(C1=CC=C(NC([C@H]2N(CCC2)C(CNC(CCC(O)=O)=O)=O)=O)C=C1O3)=CC3=O

Molecular Formula

C21H23N3O7

Molecular Weight

429.42

References & Citations

[1]Zhang B, et, al. A cell-based fluorescent assay for FAP inhibitor discovery. Bioorg Med Chem Lett. 2020 Jul 15;30 (14) :127253. |[2]Jiang D, et al. Prolyl Endopeptidase Gene Disruption Improves Gut Dysbiosis and Non-alcoholic Fatty Liver Disease in Mice Induced by a High-Fat Diet. Front Cell Dev Biol. 2021 May 20;9:628143.|[3]Venäläinen JI, et al. Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819. Biochem Pharmacol. 2002 Aug 1;64 (3) :463-71.