Tubulin polymerization-IN-59
Tubulin polymerization-IN-59 is a tubulin polymerization inhibitor and colchicine binding site inhibitor (CBSI) (IC50 = 6.1 μM) . Tubulin polymerization-IN-59 exerts potent antiproliferative activity against cancer cells, while showing lower cytotoxicity to normal cells. Tubulin polymerization-IN-59 arrests colorectal cancer HCT 116 cells in G2/M phase, induces cell apoptosis, and suppresses tumor cell colony formation and migration. Tubulin polymerization-IN-59 can be used for the study of colorectal cancer (CRC) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-59.html
Purity
99.85
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CCOC1=CC=C(C=C1F)[C@H]2CC(C3=CC(OC)=C(C(OC)=C32)OC)=O
Molecular Formula
C20H21FO5
Molecular Weight
360.38
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD35 / CR1 (E11), CF568 conjugate, 0.1mg/mL
Complement C4d (C4D204), CF594 conjugate, 0.1mg/mL
CD50 (ICAM-3) (101-1D2), CF740 conjugate, 0.1mg/mL
CD50 (ICAM-3) (186-2G9), CF594 conjugate, 0.1mg/mL
