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Prothionamide (Standard)

Prothionamide (Standard) is the analytical standard of Prothionamide. This product is intended for research and analytical applications. Prothionamide is an orally active thioamide antibacterial agent. Prothionamide is a substrate of OCT1 with a Km value of 805.8 μM. Prothionamide reacts with NAD to form a covalent adduct, with the adduct being a tight-binding inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae InhA. Prothionamide can effectively inhibit the growth of Mycobacterium tuberculosis (MIC = ~0.5 µg/mL) and Mycobacterium leprae. Prothionamide is used in the research of tuberculosis and leprosy[1][2][3][4][5].

Product Specifications

CAS Number

14222-60-7

Product Name Alternative

Protionamide (Standard)

UNSPSC

12352005

Target

Bacterial; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Others

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/prothionamide-standard.html

Smiles

S=C(C1=CC(CCC)=NC=C1)N

Molecular Formula

C9H12N2S

Molecular Weight

180.27

References & Citations

[1]Wang F, et al. Mechanism of thioamide drug action against tuberculosis and leprosy.J Exp Med. 2007 Jan 22;204 (1) :73-8.|[2]Fajardo TT, et al. A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy. Am J Trop Med Hyg. 2006 Mar;74 (3) :457-61.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

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