BI605906
BI605906, a chemical probe, is a novel IKKβ inhibitor with an IC50 value of 380 nM when assayed at 0.1 mM ATP.
Product Specifications
CAS Number
[960293-88-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IKK
Type
Reference compound
Related Pathways
NF-κB
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/BI605906.html
Purity
99.67
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=C(N)C2=C(C(F)(F)CC)C=C(N3CCC(S(=O)(C)=O)CC3)N=C2S1)N
Molecular Formula
C17H22F2N4O3S2
Molecular Weight
432.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Clark K, et al. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434 (1) :93-104.|[2]Cameron AR, et al. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. Circ Res. 2016 Aug 19;119 (5) :652-65.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKK-β
Available Sizes
Curated Selection
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