BI605906

BI605906, a chemical probe, is a novel IKKβ inhibitor with an IC50 value of 380 nM when assayed at 0.1 mM ATP.

Product Specifications

CAS Number

[960293-88-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IKK

Type

Reference compound

Related Pathways

NF-κB

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/BI605906.html

Purity

99.67

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=C(N)C2=C(C(F)(F)CC)C=C(N3CCC(S(=O)(C)=O)CC3)N=C2S1)N

Molecular Formula

C17H22F2N4O3S2

Molecular Weight

432.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Clark K, et al. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434 (1) :93-104.|[2]Cameron AR, et al. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. Circ Res. 2016 Aug 19;119 (5) :652-65.