SHP2-IN-9

SHP2-IN-9 is a specific SHP2 inhibitor (IC50 =1.174 μM) with enhanced blood–brain barrier penetration. SHP2-IN-9 shows 85-fold more selective for SHP2 than SHP1. SHP2-IN-9 inhibits SHP2-mediated cell signal transduction and cancer cell proliferation, and inhibits the growth of cervix cancer tumors and glioblastoma growth in vivo[1].

Product Specifications

CAS Number

[2987135-92-0]

Product Name Alternative

NVS-MELK8a (hydrochloride)

UNSPSC

12352005

Target

Phosphatase; SHP2

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/shp2-in-9.html

Purity

98.80

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NCC1=CC=C(C=C1)F)CN2C=NC3=C(C4=C(S3)CCCCC4)C2=O

Molecular Formula

C20H20FN3O2S

Molecular Weight

385.46

References & Citations

[1]Ma Y, et al. Structure-based discovery of a specific SHP2 inhibitor with enhanced blood-brain barrier penetration from PubChem database. Bioorg Chem. 2022;121:105648.