Bfl-1-IN-2
Bfl-1-IN-2 (Compound 13) is a reversible and covalent inhibitor of Bfl-1 (IC50: 4.3 μM) . Bfl-1-IN-2 acts by binding to Cys55 of Bfl-1[1].
Product Specifications
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bfl-1-in-2.html
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCC1(C2=CC=C(C(F)(F)F)C=C2)CC1)/C(C#N)=C/C3=CC=CC=C3P(C)(C)=O
Molecular Formula
C23H22F3N2O2P
Molecular Weight
446.40
References & Citations
[1]Simon C. C. Lucas, et al. Identification and Evaluation of ReversiblSimon C C Lucas, et al. Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen. ACS Med Chem Lett. 2024 May 20;15 (6) :791-797.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bfl-1
Available Sizes
Curated Selection
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