Avosentan
Product Specifications
UNSPSC Description
Avosentan(Ro 67-0565; SPP-301) is a potent, selective endothelin receptor(ETA receptor) antagonist. IC50 value: Target: ETA receptor
Target Antigen
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/avosentan.html
Solubility
DMSO : 6.67 mg/mL (ultrasonic)
Smiles
COC1=C(OC(C(NS(C2=NC=C(C=C2)C)(=O)=O)=NC(C3=CC=NC=C3)=N4)=C4OC)C=CC=C1
Molecular Weight
479.51
References & Citations
[1]Baltatu OC, Iliescu R, Zaugg CE, Reckelhoff JF, Louie P, Schumacher C, Campos LA.
Antidiuretic effects of the endothelin receptor antagonist avosentan.
Front Physiol. 2012;3:103.|[2]Konieczka K, Meyer P, Schoetzau A, Neutzner A, Mozaffarieh M, Flammer J.
Effect of avosentan (SPP-301) in porcine ciliary arteries.
Curr Eye Res. 2011 Feb;36(2):118-24.|[3]Mann JF, Green D, Jamerson K, Ruilope LM, Kuranoff SJ, Littke T, Viberti G; ASCEND Study Group.
J Am Soc Nephrol. 2010 Mar;21(3):527-35.|[4]Dieterle W, Hengelage T.
Absolute bioavailability and pharmacokinetics of avosentan in man.
Int J Clin Pharmacol Ther. 2009 Sep;47(9):587-94.|[5]Effect of SPP 301, an Endothelin Antagonist, on Intraocular Pressure in Glaucomatous Monkey Eyes By Wang, Rong-Fang; Podos, Steven M.; Serle, Janet B.; Baltatu, Ovidiu C. From Current Eye Research (2011), 36(1), 41-46.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15195/Avosentan-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15195/Avosentan-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
290815-26-8
Available Sizes
Curated Selection
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