Kdo2-Lipid A (ammonium)
Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both TNF and PGE2[1].
Product Specifications
CAS Number
1246298-62-3
UNSPSC
12352211
Target
TNF Receptor; Toll-like Receptor (TLR)
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kdo2-lipid-a-ammonium.html
Purity
99.00
Solubility
10 mM in DMSO
Smiles
O=C(C[C@@H](CC)OC(CC)=O)O[C@@H]([C@@H]([C@H]1CO[C@](C[C@H]([C@@H]2O)O[C@@](O[C@]([C@H]3O)([H])[C@H](O)CO)(C[C@H]3O)C(O)=O)(O[C@]2([H])[C@H](O)CO)C(O)=O)O[P](O)(O)=O)[C@H]([C@@H](O1)OC[C@@H](O[C@@H]4O[P](O)(O)=O)[C@H]([C@@H]([C@H]4NC(C[C@H](O)CC)=O)OC(C[C@H](O)CC)=O)O)NC(C[C@@H](CCC)OC(CC)=O)=O.N.N.N.[10].[12].[9].[10].[10].[10].N
Molecular Formula
C110H214N6O39P2
Molecular Weight
2306.84
References & Citations
[1]Saito O, et al. Spinal glial TLR4-mediated nociception and production of prostaglandin E (2) and TNF. Br J Pharmacol. 2010;160 (7) :1754-1764.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
Phase 4
Isoform
TLR4
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