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Kdo2-Lipid A (ammonium)

Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both TNF and PGE2[1].

Product Specifications

CAS Number

[1246298-62-3]

UNSPSC

12352211

Target

TNF Receptor; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kdo2-lipid-a-ammonium.html

Purity

99.00

Solubility

10 mM in DMSO

Smiles

O=C(C[C@@H](CC)OC(CC)=O)O[C@@H]([C@@H]([C@H]1CO[C@](C[C@H]([C@@H]2O)O[C@@](O[C@]([C@H]3O)([H])[C@H](O)CO)(C[C@H]3O)C(O)=O)(O[C@]2([H])[C@H](O)CO)C(O)=O)O[P](O)(O)=O)[C@H]([C@@H](O1)OC[C@@H](O[C@@H]4O[P](O)(O)=O)[C@H]([C@@H]([C@H]4NC(C[C@H](O)CC)=O)OC(C[C@H](O)CC)=O)O)NC(C[C@@H](CCC)OC(CC)=O)=O.N.N.N.[10].[12].[9].[10].[10].[10].N

Molecular Formula

C110H214N6O39P2

Molecular Weight

2306.84

References & Citations

[1]Saito O, et al. Spinal glial TLR4-mediated nociception and production of prostaglandin E (2) and TNF. Br J Pharmacol. 2010;160 (7) :1754-1764.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Natural Products

Clinical Information

Phase 4

Isoform

TLR4

Curated Selection

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