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2’-Fluoro-2’-deoxy-ara-C(Bz)-3’-phosphoramidite

Product Specifications

UNSPSC Description

2’-Fluoro-2’-deoxy-ara-C(Bz)-3’-phosphoramidite is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

Target Antigen

Nucleoside Antimetabolite/Analog

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-fluoro-2-deoxy-ara-c-bz-3-phosphoramidite.html

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(N=C(NC(C1=CC=CC=C1)=O)C=C2)N2[C@@H]3O[C@H](COC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H]3F

Molecular Weight

851.90

References & Citations

[1]Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.

Shipping Conditions

Blue Ice

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-154414/2-Fluoro-2-deoxy-ara-C-Bz-3-phosphoramidite-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-154414/2-Fluoro-2-deoxy-ara-C-Bz-3-phosphoramidite-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

1404463-12-2

Available Sizes

Curated Selection

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