GNE-477
GNE-477 is a potent and efficacious dual PI3K (IC50=4 nM) /mTOR (Ki=21 nM) inhibitor.
Product Specifications
CAS Number
[1032754-81-6]
UNSPSC
12352005
Hazard Statement
H317, H319
Target
MTOR; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GNE-477.html
Purity
98.75
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
NC1=NC=C(C2=NC(N3CCOCC3)=C4C(C(C)=C(CN5CCN(S(=O)(C)=O)CC5)S4)=N2)C=N1
Molecular Formula
C21H28N8O3S2
Molecular Weight
504.63
Precautions
H317, H319
References & Citations
[1]Heffron TP, et al. Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor. Bioorg Med Chem Lett. 2010 Apr 15;20 (8) :2408-11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTOR; PI3Kα
Available Sizes
Curated Selection
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